ROT1 Antibody

Datasheet

Code	CSB-PA311811XA01SVG
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Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ROT1 Polyclonal antibody

Uniprot No.

Q03691

Target Names

ROT1

Alternative Names

ROT1; YMR200W; YM8325.01; Protein ROT1; Reversal of TOR2 lethality protein 1

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ROT1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies. Controls actin cytoskeleton polarization to the mother-bud neck and CLB2 protein stability.

Gene References into Functions

Rot1 needs the transmembrane Ser250 to interact with other membrane components and to exert its functional role. PMID: 24303792
the role of Rot1 as a chaperone required to ensure proper glycosylation is demonstrated in yeast PMID: 22492205
The results show that two regions, amino acids 26-60 and 200-228, are involved in the post-translational translocation of Rot1 across the endoplasmic reticulum membrane. PMID: 20608986
Rot1p participates in protein folding with Kar2p. PMID: 16567426
study revealed a role for Rot1 in cell morphogenesis during cell cycle progression; functional antagonism between Rot1 and Clb2 is supported by genetic and biochemical data, which indicate that Rot1 is implicated in Clb2 protein degradation PMID: 17606994
Characterization of the post-translational modification, transport and membrane topology of Rot1 is reported. PMID: 17914748
is an essential molecular chaperone in the endoplasmic reticulum PMID: 18508919

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Families

ROT1 family

Database Links

KEGG: sce:YMR200W

STRING: 4932.YMR200W

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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ROT1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background