RTT107 Antibody

1. A key function of the Rtt107 BRCT domains for targeting of both itself and its interaction partners to DNA lesions was revealed. PMID: 26641499
2. The DNA repair scaffold proteins Slx4 and Rtt107 utilize a minimal multi-BRCT-domain module for phosphatase-independent downregulation of DNA damage response signals in yeast. PMID: 25896509
3. The C-terminal tandem BRCT repeats of Rtt107 interaction with gammaH2A is functionally important during DNA repair. PMID: 22262834
4. a multifaceted functional relationship between Rtt107 and Dot1 in the DNA damage response and maintenance of genome integrity. PMID: 20810656
5. identify Esc4p as an important new S-phase-specific target of monitors and participates in meiotic recombination Mec1p PMID: 14988729
6. Slx4-dependent phosphorylation of Rtt107 by Mec1 is critical for replication restart after alkylation damage. PMID: 16267268
7. Esc4 binds the Rad55/Rad56 heterodimer and forms subnuclear foci in response to DNA damage that stalls replication forks. PMID: 16569515
8. Rtt107 is recruited to chromatin following DNA damage that stalls DNA replication forks. This recruitment depends on the acetyltransferase Rtt109 and the cullin Rtt101. Chromatin-bound Rtt107 is localized at or near stalled replication forks. PMID: 17978089

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KEGG: sce:YHR154W

STRING: 4932.YHR154W