drl Antibody

Datasheet

Code	CSB-PA630635XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) drl Polyclonal antibody

Uniprot No.

Q27324

Target Names

drl

Alternative Names

drl antibody; lio antibody; CG17348Tyrosine-protein kinase Drl antibody; EC 2.7.10.1 antibody; Protein derailed antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) drl protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.

Gene References into Functions

Drl promotes dorsolateral targeting of projection neuron dendrites in developing antennal lobe. PMID: 25378162
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system. PMID: 23979591
Role of the cytoplasmic domain and the kinase activity of the linotte/derailed receptor tyrosine kinase in adult brain development. PMID: 15611849
Both the Wnt4-frizzled pathway and a separate Wnt5-derailed pathway are needed for proper salivary gland migration in Drosophila embryogenesis. PMID: 17507403
Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor. Mutations in both wnt5 and drl result in a significant reduction in the number of synaptic boutons. PMID: 17963254
Derailed protein receptor (Drl) is localized in developing olfactory glomeruli and mediates Wnt5 signaling. PMID: 19369566

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Subcellular Location

Cell membrane; Single-pass membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family

Tissue Specificity

In the embryonic abdominal hemisegment, expression is restricted to cell body, axon and growth cone of a cluster of 20 ventral nerve cord interneurons. During muscle growth and attachment events in the embryonic abdominal hemisegment, expression is in som

Database Links

KEGG: dme:Dmel_CG17348

STRING: 7227.FBpp0303242

UniGene: Dm.4108

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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drl Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background