S100a4 Antibody

Code CSB-PA020632ZA01RA
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) S100a4 Polyclonal antibody
Uniprot No. P05942
Target Names S100a4
Alternative Names S100a4 antibody; Protein S100-A4 antibody; Metastasin antibody; Nerve growth factor-induced protein 42A antibody; P9K antibody; Placental calcium-binding protein antibody; S100 calcium-binding protein A4 antibody
Raised in Rabbit
Species Reactivity Rattus norvegicus
Immunogen Recombinant Rat Protein S100-A4 (S100a4) (2-101AA)
Immunogen Species Rattus norvegicus (Rat)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors.
Gene References into Functions
  1. Data indicate that microRNA miR-124 targets S100 calcium-binding protein A4 (S100A4) 3' UTR and regulates vascular smooth muscle cell proliferation. PMID: 28235243
  2. S100A4 is upregulated in the experimental rat periodontitis. PMID: 26499072
  3. Results show S100A4 expression increasing during fibrotic stage and declining during resolution suggesting it as a good marker for liver fibrogenesis. PMID: 26721462
  4. found a significant increase in the expression of S100A4 in vitreous samples of rats with diabetic retinopathy PMID: 25253987
  5. TG2 regulates S100A4-mediated mammary tumor cell migration. PMID: 23469180
  6. S100A4 modulates p53 function in fibroblasts and thereby mediates myocardial interstitial fibrosis through two distinct mechanisms; cell proliferation and collagen expression. PMID: 23352991
  7. The concentration gradient of S100A4 induces direction guidance for neurons and astrocytes. PMID: 23222508
  8. S100A4 downregulates filopodia formation through increased dynamic instability PMID: 21975553
  9. The presence of S100A4 in sensory neurons, including their processes in the central nervous system, suggests that S100A4 is involved in propagation of sensory impulses in specific fiber types. PMID: 15101091
  10. results indicated that S100A4 may play a role as a possible target molecule for TCR gamma delta T cell-mediated lysis although how S100A4 is involved in TCR gamma delta T cell-mediated lysis remains to be determined PMID: 15665453
  11. the ability to interact with protein target(s) is important in S100A4-induced metastasis PMID: 15856021
  12. S100A4 has a stabilizing function in reactive white matter astrocytes PMID: 16265672
  13. high-grade glioblastomas express higher amount of S100A4/Mts1 than low-grade astrocytic tumors PMID: 17223348

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Subcellular Location Secreted. Nucleus. Cytoplasm.
Protein Families S-100 family
Database Links

KEGG: rno:24615

STRING: 10116.ENSRNOP00000015958

UniGene: Rn.504

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