Scm Antibody

1. loss-of-function mutations in Scm result in non-autonomous tissue overgrowth in Drosophila, and determine that Scm is essential for ommatidium development and important for cell survival in Drosophila PMID: 25772304
2. Scm coordinates PcG complexes and polymerizes to produce broad domains of PcG silencing PMID: 26063573
3. SUMO negatively regulates Scm function by impeding its recruitment to the Ubx major PRE. PMID: 21278366
4. Data show that Sex Comb on Midleg (SCM) associates with a Polycomb response element upstream of the Ubx gene which also binds PRC1, PRC2, and the DNA-binding PcG protein Pleiohomeotic. PMID: 20351181
5. SCM interacts and functions with Polycomb repressive complex 1 in gene silencing. PMID: 15280237
6. polymeric Scm complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression PMID: 15905166
7. Data show that the MBT domain of Sex comb on midleg and its methyl-lysine-binding activity are required for repression of Hox genes. PMID: 17932512
8. Testing the role of this structure in male mating success in Drosophila melanogaster, the sex comb was removed by expressing the female-specific isoform of the sex determination gene transformer in the tarsal segments of male legs. PMID: 18213513

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KEGG: dme:Dmel_CG9495

STRING: 7227.FBpp0081580

UniGene: Dm.6241