sdn-1 Antibody

Datasheet

Code	CSB-PA341895XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans sdn-1 Polyclonal antibody

Uniprot No.

P50605

Target Names

sdn-1

Alternative Names

sdn-1 antibody; F57C7.3 antibody; Probable syndecan antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans sdn-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Cell surface proteoglycan that bears heparan sulfate. Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2. Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts. Promotes the axon guidance of D-type motor neurons.

Gene References into Functions

SDN-1 controls cell migration in nervous system in coordination with Wnt signaling. PMID: 28576860
The sdn-1 mutants showed QR descendant AQR anterior migration defects, and weaker QL descendant PQR migration defects. PMID: 26022293
Syndecan's core protein, not its sugar chains, mediates growth cone stabilization. Syndecan also functions in axon guidance via its sugar chains. PMID: 25001284
SDN-1 is required for precise orientation of the mitotic spindle in response to a Wnt cue in development. PMID: 25344071
syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva PMID: 15456854
distinct heparan sulfate modification patterns on SDN-1 are involved in regulating axon guidance and cell migration in C. elegans PMID: 16176946
SDN-1 affects UNC-5 function by regulating the proper extracellular distribution of growth factors PMID: 19631636

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Subcellular Location

Membrane; Single-pass type I membrane protein. Cell surface. Cell junction. Cytoplasm.

Protein Families

Syndecan proteoglycan family

Database Links

STRING: 6239.F57C7.3a.1

UniGene: Cel.23080

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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sdn-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background