secY Antibody

1. These data suggest that wild-type YidC residues (G355 and M471) participate in interactions, direct or indirect, with SecY. PMID: 24187090
2. While translocation of loops 1 and 2 of TatC is strictly dependent on the Sec translocase and the YidC insertase, translocation of loop 3 does not depend on the translocase or insertase. PMID: 23058713
3. SecY signal peptide is found to specifically bind SecY translocase in a saturable manner and at levels comparable to those that stimulate SecA ATPase activity. PMID: 15476412
4. provide evidence for the direct interaction between FtsY and the SecY translocon PMID: 15815684
5. SecY plug domain moves away from the center of the channel toward SecE during polypeptide translocation, and the translocation-enhancing prlA3 mutation and SecG subunit change the properties of channel gating. PMID: 16148946
6. The data explain how conformational changes in SecA could be directly coupled to the previously proposed opening mechanism of the SecYEG channel. PMID: 16890955
7. One such translocation complex, SecY/Sec61, is found in every cell, in either the plasma membrane of bacteria and archaea or the endoplasmic reticulum membrane of eukaryotes. PMID: 17077865
8. the SecY plug contributes to the gating mechanism of the channel by maintaining the structure of the SecYEG complex in a compact closed state PMID: 17092931
9. normal SecY function is required for the folding of membrane proteins after their insertion into the translocon PMID: 17242069
10. study used purified E. coli components to address the mechanism of protein translocation; disulfide bridge crosslinking demonstrates that SecA transfers both the signal sequence and the mature region of a secreted substrate into a single SecY molecule PMID: 17418789
11. The resting cell membrane channel forms a barrier for small molecules, with both the pore ring and the plug required for the seal; channel opening requires movement of the plug. PMID: 17531809
12. Data suggest that SecY binds to the primary site on the ribosome and subsequently captures and translocates the nascent chain. PMID: 18158904

Show More

Hide All

KEGG: ecj:JW3262

STRING: 316385.ECDH10B_3475