sgk-1 Antibody

Datasheet

Code	CSB-PA650826XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans sgk-1 Polyclonal antibody

Uniprot No.

Q2PJ68

Target Names

sgk-1

Alternative Names

sgk-1 antibody; W10G6.2 antibody; Serine/threonine-protein kinase sgk-1 antibody; EC 2.7.11.1 antibody; Serum- and glucocorticoid-inducible kinase homolog antibody; Serum/glucocorticoid-regulated kinase 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans sgk-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Promotes the cytoplasmic localization of the transcription factor pqm-1. Plays a role in the intracellular trafficking of proteins such as mig-14 to the cell membrane, and this may be through positively regulating ceramide synthesis. Acts downstream of rict-1 to regulate fat storage, size, development and vitellogenesis. Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development. Does not appear to play a role in immune function.

Gene References into Functions

SGK-1 acts in parallel to the AKT kinases to mediate DAF-2 signaling. Loss of sgk-1 results in defective egg-laying, extended generation time, increased stress resistance, and an extension of life span. PMID: 15068796
findings indicate that SGK-1 is a mediator of Rictor activity; findings identify new physiological roles for TORC2, mediated by SGK, in regulation of C. elegans lipid accumulation and growth PMID: 19260765

Subcellular Location

Cytoplasm. Nucleus. Apical cell membrane.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family

Tissue Specificity

Expressed in late embryos just before hatching. At postembryonic stages, expressed in sensory and motor neurons and in the intestine. Highly expressed in the intestine and head and tail neurons.

Database Links

KEGG: cel:CELE_W10G6.2

STRING: 6239.W10G6.2b

UniGene: Cel.19781

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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sgk-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background