sn Antibody

1. Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture. PMID: 25808493
2. essential for actin bundle initiation and stiffening during embryonic tracheal system development PMID: 25482727
3. Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle. PMID: 24591594
4. Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis. PMID: 24496629
5. These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling PMID: 23051736
6. The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not. PMID: 22764047
7. The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types. PMID: 19901519
8. Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin. PMID: 16928862
9. Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding. PMID: 19592575
10. study found that Rab35 regulates the assembly of actin filaments during bristle development; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35 PMID: 19729655

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KEGG: dme:Dmel_CG32858

STRING: 7227.FBpp0290893

UniGene: Dm.7274