SLD3 Antibody

Code CSB-PA345260XA01SVG
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SLD3 Polyclonal antibody
Uniprot No.
Target Names
SLD3
Alternative Names
SLD3 antibody; YGL113W antibody; G2980 antibody; DNA replication regulator SLD3 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SLD3 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.
Gene References into Functions
  1. Here, the crystal structure of Sld7 in complex with Sld3 is presented. Sld7 comprises two structural domains. PMID: 26249346
  2. The crystal structure of the central domain of Sld3 from Saccharomyces cerevisiae. PMID: 25126958
  3. CDK substrates Sld3 and Sld2 and their binding partner Dpb11, together with the DDK subunit Dbf4 control S-phase length in budding yeast Saccharomyces cerevisiae limiting replication initiationst hrough their low abundance. PMID: 22081107
  4. replication initiation protein Sld3 is phosphorylated by Rad53, and that this phosphorylation, along with phosphorylation of the Cdc7 kinase regulatory subunit Dbf4, blocks late origin firing in Saccharomyces cerevisiae PMID: 20865002
  5. Sld3 does not move with DNA replication forks and only associates with MCM in an unstable manner before initiation. PMID: 16601689
  6. Dpb11 connects phosphorylated Sld2 and Sld3 to facilitate interactions between replication proteins, such as Cdc45 and GINS PMID: 17167415
  7. Sld2 and Sld3 are the minimal set of cyclin-dependent kinase targets required for DNA replication PMID: 17167417

Show More

Hide All

Subcellular Location
Nucleus.
Database Links

KEGG: sce:YGL113W

STRING: 4932.YGL113W

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1