smc6 Antibody

1. Study shows that the Smc5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the Smc5/6 complex. PMID: 28134253
2. Results provide evidence that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/6 complex at damaged replication forks. PMID: 28784724
3. The function of the SMC5/6 complex and its mammalian homologs in the cell cycle has not been clarified yet. PMID: 26743946
4. Smc6 is a required for homologous recombination in S. pombe. PMID: 21976700
5. Smc6 contributes to DNA repair in vivo by targeting the Smc5-6 complex to single-stranded DNA substrates created during the processes of homologous recombination and/or DNA replication. PMID: 22086171
6. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that several MAGE proteins can interact with at least one of the NSE4/EID proteins. PMID: 21364888
7. there are two subcomplexes containing Rad18-Spr18-Nse2 and Nse1-Nse3-Rad62, which are probably bridged by a weaker interaction between Nse2 and Nse3 PMID: 15601840
8. analysis of bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits in the Smc5-Smc6 DNA repair complex PMID: 17005570
9. When replication forks collapse, Smc6 (formerly known as rad18) is required for the effective repair of lesions but not for the recruitment of recombination proteins. PMID: 17030601
10. Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function. PMID: 17277362
11. Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions PMID: 18667531
12. Data suggest that localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively. PMID: 18923417
13. Smc5/6 is required to maintain stalled forks in a stable recombination-competent conformation primed for replication restart. PMID: 19158664
14. Data show that defective cohesin removal is a major determinant of the mitotic lethality of Smc5-Smc6 mutants. PMID: 19528228

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KEGG: spo:SPCC5E4.06

STRING: 4896.SPCC5E4.06.1