sna Antibody

1. While either Snail or Serpent induced a profound loss of epithelial polarity and tissue organisation, Serpent but not Snail also induced an increase in the size of wing discs. Furthermore, the Serpent-induced tumour-like tissues were able to grow extensively when transplanted into the abdomen of adult hosts. PMID: 29420531
2. Disruption of Snail expression in follicle stem cells compromises proliferation, but not maintenance. FSCs with excessive Snail expression had increased proliferation and lifespan, accompanied by a moderate decrease inE-cadherin expression (required for adhesion of FSCs to their niche) at the junction between their adjacent cells, indicating a conserved role of Snail in E-cadherin inhibition. PMID: 27141871
3. during gastrulation of Drosophila embryos, Sna expression downregulates polarity protein Baz which in turn results in junction disassembly at protein levels. PMID: 28063874
4. Snail can potentiate enhancer activation by collaborating with different activators, providing a new mechanism by which Snail regulates development. PMID: 24402316
5. Rapid transcription kinetics and negative autoregulation are responsible for the remarkable homogeneity of snail expression and the coordination of mesoderm invagination. PMID: 23352665
6. Study shows that Sna represses transcription of pbl in the mesoderm primordium of D. melanogaster via one or more Sna-binding sites, which are conserved among species of the Drosophila genus, but not in the mosquito, correlating with the different modes of gastrulation in the different genuses. PMID: 22945369
7. Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression. PMID: 21813571
8. Dorsal activates twist and snail, and the Dorsal/Twist/Snail network activates and represses other zygotic genes to form the dorsoventral axis in Drosophila. PMID: 15987775
9. Snail represses Tom expression in the mesoderm and thereby activates Delta trafficking. PMID: 16459304

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KEGG: dme:Dmel_CG3956

STRING: 7227.FBpp0080298

UniGene: Dm.3035