sox3 Antibody

1. these findings show that sox2 and sox3 are together required for proper otic induction, but the level of expression must be tightly regulated to avoid suppression of differentiation and maintenance of pluripotency. PMID: 29355522
2. these data show that sox2 and sox3 exhibit intrinsic differences in promoting sensory vs. neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a and fgf8 also modify sox2/3 functions. PMID: 29355523
3. significant decreases in sox3 (up to 3-fold) expression following chilling. Significant increases in expression of sox3 (up to 33-fold) during warming of chilled zebrafish embyos. PMID: 21820425
4. Knockdown of fgf24 or sox3 causes severe epibranchial deficiencies but has little effect on otic development PMID: 21215261
5. Knockdown of the four B1 sox genes sox2/3/19a/19b resulted in severe developmental abnormalities. PMID: 20463883
6. The pro-neural effects of Sox3 can compensate for inhibition of fibroblast growth factor (Fgf) signalling in inducing neural tissue but it is not sufficient to maintain neural fate, suggesting the presence of Sox3-independent roles of Fgf at later stages. PMID: 18572157

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KEGG: dre:30529

STRING: 7955.ENSDARP00000070099

UniGene: Dr.104569