spe-39 Antibody

Code CSB-PA633812XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans spe-39 Polyclonal antibody
Uniprot No.
Target Names
spe-39
Alternative Names
spe-39 antibody; vipar antibody; ZC404.3 antibody; Spermatogenesis-defective protein 39 antibody; SPE-39 antibody; VPS33B-interacting protein in polarity and apical restriction antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans spe-39 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Proposed to be involved in endosomal maturation implicating in part vps-33.2. May play a role in epithelial polarization through stabilization of apical membrane protein content. May play a role in transcriptional regulation. Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. Essential for vesicular trafficking during spermatogenesis; required during spermiogenesis or sperm activation for the morphogenesis of specialized Golgi-derived fibrous body-membranous organelle (FB-MO) complexes. Required for the processing of internalized proteins in oocytes and coelomocytes.
Gene References into Functions
  1. SPE-39 homologues are present in RAB5-, RAB7-, and RAB11-positive endosomes where they play a conserved role in lysosomal delivery and probably function via their interaction with the core HOPS complex. PMID: 19109425
Subcellular Location
Cytoplasm. Cytoplasmic vesicle. Early endosome. Recycling endosome. Late endosome.
Protein Families
SPE39 family
Tissue Specificity
Expressed in spermatocytes and spermatids (at protein level).
Database Links

KEGG: cel:CELE_ZC404.3

STRING: 6239.ZC404.3a

UniGene: Cel.17954

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