Spns2 Antibody

1. genome-wide in vivo screen identifies novel host regulators of metastatic colonization, such as Spns2 PMID: 28052056
2. results point to a broad role for Spns2-mediated S1P transport in the initiation and development of adaptive immune related disorders PMID: 26324848
3. Spns2 expression by endothelial cells is essential for secretion of lymph S1P, while Spns2 is dispensable for RBC secretion of plasma S1P. PMID: 23103166
4. Spns2 is an S1P transporter in vivo that plays a role in regulation not only of blood S1P but also lymph node and lymph S1P levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization. PMID: 23180825
5. SPNS2 is the first physiological S1P transporter in mammals and is a key determinant of lymphocyte egress from the thymus. PMID: 22723910
6. The changes in lymphocyte subpopulations in mutant Spns2 mice closely mimick the phenotypes of partial sphingosine-1-phosphate (S1P) deficiency, impaired S1P-dependent lymphocyte trafficking, and depletion of circulating lymphocytes. PMID: 22664872
7. Spns2 functions in endothelial cells to establish the S1P gradient required for T and B cells to egress from their respective primary lymphoid organs. PMID: 22406534
8. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. PMID: 21084291

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KEGG: mmu:216892

STRING: 10090.ENSMUSP00000044418

UniGene: Mm.212812