SPT6 Antibody

1. Results provide evidence that both FACT and Spt6 are important for transcription globally and may participate during different stages of transcription. PMID: 29695490
2. Interactions between SPT6 and RNA Polymerase II PMID: 27261007
3. Results demonstrate that a fine-tuning of the Spt16 component of FACT by UPS is essential for proper chromatin reassembly and efficient transcriptional elongation, thus revealing a novel ubiquitin proteasome system regulation of FACT with physiological relevance in gene expression. PMID: 27044865
4. Histone chaperones FACT and Spt6 are important for appropriate H2AZ histone localization and for the functioning of RNA polymerase II. PMID: 26990181
5. Data show that the histone chaperones POB3 protein FACT and chromatin-remodeling histone chaperone Spt6 prevent widespread accumulation of histone H2A.Z. PMID: 25959393
6. Spt6 is involved in either recruiting the Pol I-Rrn3 complex to the rDNA or stabilizing the preinitiation complex. The findings presented here identify an unexpected, essential role for Spt6 in synthesis of rRNA. PMID: 25918242
7. Data suggest that phosphorylation of the Pol II C-terminal domain on Tyr1 promotes the association of Spt6 with the 3' ends of transcribed genes, independently of Ser2 phosphorylation. PMID: 25182531
8. A report on the mechanism involving Spt6 and Ctk1 in the regulation and maintenance of RNA polymerase II Ser2 C-terminal domain phosphorylation during transcription elongation. PMID: 24163256
9. Spt6 may use the tandem SH2 domain module to sense the phosphorylation level of RNAPII CTD. PMID: 21676864
10. these findings provide a structural foundation for understanding how Spt6 encodes several distinct functions within a single polypeptide chain. PMID: 21419780
11. results provide new evidence for a connection between the transcription elongation factor Spt6 and RNA 3'-end formation in vivo PMID: 15531585
12. Results identify Spt6 as the factor that mediates nucleosome reassembly onto the PHO5 and other promoters during transcriptional repression. PMID: 16455495
13. These findings link Spn1 functions to the transition from an inactive to an actively transcribing RNAPII complex at a postrecruitment-regulated promoter. PMID: 18086892
14. The C-terminal region of Set2, in conjunction with the phosphorylated C-terminal domain of RNAPII, influences the KMTase activity to promote methylation of histone H3 at lysine 36 during transcription elongation. PMID: 18541663
15. The SH2 domain is required for normal expression of a subset of yeast genes, and is consistent with multiple functions of Spt6 in chromatin transcription. PMID: 19371747

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KEGG: sce:YGR116W

STRING: 4932.YGR116W