mtSSB Antibody

Code CSB-PA347528XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) mtSSB Polyclonal antibody
Uniprot No.
Target Names
mtSSB
Alternative Names
mtSSB antibody; lopo antibody; CG4337 antibody; Single-stranded DNA-binding protein antibody; mitochondrial antibody; Dm mtSSB antibody; Mt-SSB antibody; MtSSB antibody; Protein low power antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) mtSSB protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase tam at the replication fork. Promotes tam activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate tam activity.
Gene References into Functions
  1. The stimulatory effect of mtSSB on Pol gamma on these ssDNA templates is not species-specific. PMID: 26446790
  2. mtSSB uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells PMID: 21953457
Subcellular Location
Mitochondrion.
Tissue Specificity
Uniformly distributed in the early embryo. High levels detected in the anterior and posterior midgut primordia of stage 12 embryos. In larvae, high levels were detected in proliferating tissues including the CNS and digestive tract. In adults, highly expr
Database Links

KEGG: dme:Dmel_CG4337

STRING: 7227.FBpp0099503

UniGene: Dm.5334

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