STM1 Antibody

Code CSB-PA334507XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) STM1 Polyclonal antibody
Uniprot No.
Target Names
STM1
Alternative Names
STM1 antibody; MPT4 antibody; STO1 antibody; YLR150W antibody; L9634.1 antibody; Suppressor protein STM1 antibody; 3BP1 antibody; GU4 nucleic-binding protein 2 antibody; G4p2 protein antibody; POP2 multicopy suppressor protein 4 antibody; Ribosomal subunits association factor antibody; AF antibody; TOM1 suppressor protein 1 antibody; Triplex-binding protein 1 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) STM1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilized by guanine base quartets) and purine motif triplex (characterized by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures. These structures may be present at telomeres or in rRNAs. Acts with CDC13 to control telomere length homeostasis. Involved in the control of the apoptosis-like cell death.
Gene References into Functions
  1. These findings suggest that Stm1p can act as a ribosome preservation factor under conditions of nutrient deprivation and restoration. PMID: 23206692
  2. Stm1 may recognize the shape of the triplex rather than the base sequence of the triplex. PMID: 18776278
  3. Stm(amino acids 1-113) is the minimal domain to specifically bind with the purine motif triplex. PMID: 18029617
  4. Stm1 loss-of-function alleles and overexpression strains show several genetic interactions with Pat1 and Dhh1 alleles in a manner consistent with Stm1 working upstream of Dhh1 to promote Dhh1 function. PMID: 19015546
  5. data indicates that Stm1p plays a complementary role to eEF3 in translation. PMID: 19666721

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Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Concentrated in the perinuclear region.
Database Links

KEGG: sce:YLR150W

STRING: 4932.YLR150W

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