Serpina3k Antibody

Code CSB-PA361549ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Serpina3k Polyclonal antibody
Uniprot No.
Target Names
Serpina3k
Alternative Names
Serine protease inhibitor A3K (Serpin A3K) (CPI-21) (Contrapsin-like protease inhibitor 1) (GHR-P63) (Growth hormone-regulated proteinase inhibitor) (Kallikrein-binding protein) (KBP) (SPI-2.3) (Serine protease inhibitor 2) (SPI-2) (Thyroid hormone-regulated protein), Serpina3k, Spin2b
Raised in
Rabbit
Species Reactivity
Rattus norvegicus
Immunogen
Recombinant Rattus norvegicus Serpina3k protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase.
Gene References into Functions
  1. KBP suppressed lipopolysaccharide-induced TNF-alpha production via upregulating SOCS3 expression. PMID: 23129128
  2. KBP competed with (125)I-VEGF for binding to endothelial cells and down-regulated VEGF production in endothelial cells and in the retina of the oxygen-induced retinopathy rat model PMID: 12743698
  3. in a rat model of chronic mycardial infarction (MI) kallistatin improves cardiac performance and prevents post-MI-induced cardiac hypertrophy and fibrosis through its antioxidant action. PMID: 18762777
  4. An inverse relationship exists between oxidative stress and kallistatin levels in the circulation and blood vessels. Kallistatin expression is negatively regulated by oxidative stress via JNK-dependent FOXO1 activation in cultured endothelial cells. PMID: 20081110
  5. Pivotal role for alpha1-antichymotrypsin in skin repair PMID: 21693707
  6. SERPINA3K is an antifibrogenic factor, and its antifibrogenic activity is through blocking the Wnt pathway. Decreased SERPINA3K levels may contribute to the fibrosis in diabetic retinopathy. PMID: 20299474
  7. SERPINA3K is a high-affinity, endogenous antagonist of LRP6 PMID: 20351274

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Subcellular Location
Secreted.
Protein Families
Serpin family
Tissue Specificity
Liver and plasma.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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