hly Antibody

1. Listeriolysin O -induced down-regulation of Ubc9 is independent of Ubc9-SUMO interaction, however, it may involve phosphorylation signaling. PMID: 28911869
2. During infection, PML undergoes oxidation-mediated multimerization, associates with the nuclear matrix, and becomes de-SUMOylated due to the pore-forming activity of the Listeria toxin listeriolysin O (LLO). PMID: 28074026
3. The current MD simulation work provides insights into the mechanism by which the compounds inhibit LLO at the atomic level and will be useful for the development of new, selective LLO inhibitors. PMID: 25749652
4. Listeria L. monocytogenes induced decrease in hTERT levels is triggered by listeriolysin O (LLO). PMID: 23006849
5. findings show that listeriolysin O and other cholesterol-dependent cytolysins induce K+ efflux through pore formation at the cell membrane PMID: 21482680
6. Data suggest that CFTR transiently increases phagosomal chloride concentration after infection, potentiating LLO pore formation and vacuole lysis. PMID: 21220348
7. These data showed that listeriolysin O-mediated cytoplasmic entry of Listeria monocytogenes could induce the activation of intracellular calcium signaling, which is essential for maturation and secretion of IL-1 alpha in macrophages. PMID: 20194588
8. L. monocytogenes-infected human PBMCs produced IL-1beta, largely depending on an LLO-mediated phagosomal rupture and cathepsin B release, which is sensed by Nlrp3 PMID: 20008285
9. These results reveal the importance of the 91-99 region in the production of a stable and functional LLO. LD(50) determinations in the mouse model suggest a possible link between LLO stability and virulence. PMID: 16622046
10. Listeria monocytogenes-induced caspase-1 activation and interferon-gamma production in mouse macrophages is ascribed mainly to the presence of listeriolysin O. PMID: 18523249

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KEGG: lmo:lmo0202

STRING: 169963.lmo0202