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Tracheal antimicrobial peptide Antibody

Datasheet
Code CSB-PA328513XA01BO
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Product Details

Uniprot No.
P25068
Alternative Names
antibody; Tracheal antimicrobial peptide antibody; TAP antibody
Raised in
Rabbit
Species Reactivity
Bos taurus (Bovine)
Immunogen
Recombinant Bos taurus (Bovine) Tracheal antimicrobial peptide protein
Immunogen Species
Bos taurus (Bovine)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Has antibacterial activity in vitro against Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa. In addition, the peptide is active against Candida albicans, indicating a broad spectrum of activity.
Gene References into Functions
  1. Sequencing of exon 2 of the TAP gene from 23 cattle revealed a prevalent non-synonymous single nucleotide polymorphism (SNP) A137G, encoding either serine or asparagine at residue 20 of the mature peptide. PMID: 23333196
  2. Twenty four hours post E. coli stimulation, IL1b, IL6, IL8, TNF and LAP gene expression was decreased compared to 6h, whereas TAP and SAA3 expression was further increased to 209- and 3452-fold (P<0.05). PMID: 23200820
  3. The results from this study clearly demonstrate the involvement of octamer transcription factor-1 in the regulation of tracheal antimicrobial peptide and lingual antimicrobial peptide expression. PMID: 21674298
  4. The production of tracheal antimicrobial peptide in mammary epithelial cells in reponse to bacteria, drugs, and prolactins is reported. PMID: 19181355
Subcellular Location
Secreted.
Protein Families
Beta-defensin family, LAP/TAP subfamily
Tissue Specificity
Tracheal epithelium.
Database Links

KEGG: bta:286837

STRING: 9913.ENSBTAP00000056499

UniGene: Bt.510

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