Product Details

Full Product Name

Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) taz1 Polyclonal antibody

Uniprot No.

P79005

Target Names

taz1

Alternative Names

taz1 antibody; myb antibody; myb1 antibody; SPAC16A10.07c antibody; Telomere length regulator taz1 antibody

Raised in

Rabbit

Species Reactivity

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Immunogen

Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) taz1 protein

Immunogen Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis.

Gene References into Functions

Taz1-Shelterin promotes facultative heterochromatin assembly at chromosome-internal sites containing late replication origins. PMID: 27264871
Centromere detachment required telomere clustering-dependent spindle pole body recruitment of Taz1 and microtubules. PMID: 27611693
Data indicate the differences in requirements of DNA-binding protein Teb1p and telomere-binding protein Taz1p for DNA binding PMID: 27101289
telomere-binding protein Taz1 plays a crucial role in the control of replication timing in fission yeast PMID: 22987637
Taz1 is required for cell-cycle restriction of telomerase activity PMID: 22633956
the truncation of Taz1 protein is based on structural properties of taz1(+) mRNA. PMID: 20074552
Taz1 binds to the telomere at the 3' overhang, then extrudes a loop that grows in size as the donut slides along the duplex DNA PMID: 15383525
Taz1 can function independently of its known binding partners to maintain telomeres PMID: 16096639
Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. PMID: 16243027
loss of Taz1 leads to stalled replication forks at telomeres and internally placed telomere sequences, regardless of whether the telomeric G-rich strand is replicated by leading- or lagging-strand synthesis PMID: 16598261

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Subcellular Location

Cytoplasm. Nucleus. Chromosome, telomere.

Database Links

KEGG: spo:SPAC16A10.07c

STRING: 4896.SPAC16A10.07c.1

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taz1 Antibody

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