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Recombinant Schizosaccharomyces pombe Telomere length regulator taz1 (taz1), partial

Recombinant Schizosaccharomyces pombe Telomere length regulator taz1 (taz1), partial

Code	CSB-YP301278SXV
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP301278SXV
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP301278SXV-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP301278SXV
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP301278SXV
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

taz1

Uniprot No.

P79005

Alternative Names

taz1; myb; myb1; SPAC16A10.07c; Telomere length regulator taz1

Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis.

Gene References into Functions

Taz1-Shelterin promotes facultative heterochromatin assembly at chromosome-internal sites containing late replication origins. PMID: 27264871
Centromere detachment required telomere clustering-dependent spindle pole body recruitment of Taz1 and microtubules. PMID: 27611693
Data indicate the differences in requirements of DNA-binding protein Teb1p and telomere-binding protein Taz1p for DNA binding PMID: 27101289
telomere-binding protein Taz1 plays a crucial role in the control of replication timing in fission yeast PMID: 22987637
Taz1 is required for cell-cycle restriction of telomerase activity PMID: 22633956
the truncation of Taz1 protein is based on structural properties of taz1(+) mRNA. PMID: 20074552
Taz1 binds to the telomere at the 3' overhang, then extrudes a loop that grows in size as the donut slides along the duplex DNA PMID: 15383525
Taz1 can function independently of its known binding partners to maintain telomeres PMID: 16096639
Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. PMID: 16243027
loss of Taz1 leads to stalled replication forks at telomeres and internally placed telomere sequences, regardless of whether the telomeric G-rich strand is replicated by leading- or lagging-strand synthesis PMID: 16598261