TFC3 Antibody

Datasheet

Code	CSB-PA339415XA01SVG
Size	US$299
Image	Western Blot Positive WB detected in Recombinant protein All lanes: TFC3 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 56.1 kDa Observed band size: 63 kDa
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Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TFC3 Polyclonal antibody

Uniprot No.

P34111

Target Names

TFC3

Alternative Names

TFC3 antibody; TSV115 antibody; YAL001C antibody; FUN24 antibody; Transcription factor tau 138 kDa subunit antibody; TFIIIC 138 kDa subunit antibody; Transcription factor C subunit 3 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TFC3 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Protein A/G

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The immune response in a rabbit is stimulated by injecting it with the recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TFC3 protein. After some time, the rabbit's immune system produces antibodies against the TFC3 protein. When enough antibodies have been generated, a serum sample is collected to obtain polyclonal antibodies. The TFC3 antibody undergoes protein A/G affinity chromatography purification. The TFC3 antibody's efficacy is assessed in ELISA and WB applications, and it reacts specifically with the Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TFC3 protein.

The Saccharomyces cerevisiae TFC3 protein, a component of the RNA polymerase III (Pol III) transcription factor complex, mainly regulates the expression of genes involved in the synthesis of small RNA molecules such as tRNAs and 5S rRNA. TFC3 specifically binds to the promoter region of these genes and recruits other components of the Pol III complex to initiate transcription.

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Target Background

Function

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.

Gene References into Functions

tau55-HPD and Huf as bona fide protein phosphatases, characterize their substrate specificities, and provide a small set of regulated phosphosite targets in vivo. PMID: 23569204
the TFC6 promoter is directly regulated by the TF(III)C complex, a demonstration of an RNA polymerase II promoter being directly responsive to a core Pol III transcription factor complex. PMID: 21536876
Partially assembled Pol III complexes containing only the TFIIIC exhibit chromatin boundary functions both as heterochromatin barriers and as insulators to gene activation. PMID: 18849469

Subcellular Location

Nucleus. Mitochondrion.

Database Links

KEGG: sce:YAL001C

STRING: 4932.YAL001C

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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TFC3 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background