tim Antibody

1. data suggest that CRTC is a novel co-activator for the CLK/CYC-activated tim transcription to coordinate molecular rhythms with circadian behaviors over a 24-hour time-scale. PMID: 27577611
2. A phosphorylation program, native to the master pacemaker neurons, regulates the timing of nuclear accumulation of the Period/Timeless repressor complex. PMID: 27346344
3. mir-276a inhibits tim expression: Deleting the mir-276a-binding site in the tim 3' UTR causes elevated levels of TIM and approximately 50% arrhythmicity. PMID: 27162360
4. possible roles it plays in the physiological preservation of health, as well as in the pathogenic mechanisms of related diseases [review] PMID: 26691298
5. CULLIN-3 is required for the circadian control of PERIOD and TIMELESS oscillations. PMID: 22879814
6. Nuclear TIM expression is associated with day-night cycles that are independent of the central nervous system. PMID: 22713751
7. Timeless regulates phagocytosis of bacteria in Drosophila. PMID: 22253593
8. This study demonstrated that timelss mutant affect TIMELESS and PERIOD post-trnaslational regulation and metabolism in cell nuclear. PMID: 21734289
9. structural domains PMID: 12372263
10. Tim1 has a role in sister chromatid cohesion. PMID: 12852847
11. Regulation of the timeless protein involves nuclear transport mechanisms. PMID: 12944510
12. A novel tim mutation affects behavioral rhythms but not periodic eclosion. PMID: 15520259
13. results suggest that JET is essential for resetting the circadian clock by transmitting light signals from cryptochrome to TIMELESS PMID: 16794082
14. Results suggest that photic stimulation of timeless expression at low temperatures is part of a seasonal adaptive response that helps advance the clock phase on cold days, enabling flies to exhibit daytime activity despite the earlier onset of dusk. PMID: 16864646
15. Data show that ectopic CRYPTOCHROME renders TIMELESS light-sensitive in the Drosophila ovary. PMID: 16864647
16. show a strong interaction between Veela and cryptochrome genetic variants, demonstrating that the Jetlag, Timeless, and cryptochrome proteins function in the same pathway PMID: 17068124
17. study reports that a mutation in the timeless gene has arisen and spread by natural selection relatively recently in Europe; natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light & temperature PMID: 17600215
18. findings show that the mutant allele attenuates the photosensitivity of the circadian clock and causes decreased dimerization of the mutant TIMELESS protein isoform to CRYPTOCHROME; this interaction results in a more stable TIMELESS product PMID: 17600216
19. these data indicate that TIM is an important mediator of CK2 effects on circadian rhythms. PMID: 18815259

Show More

Hide All

KEGG: dme:Dmel_CG3234

STRING: 7227.FBpp0305454

UniGene: Dm.2663