Tis11 Antibody

1. Data indicate that Tis11 protein can affect post-transcriptional gene expression in adult flies by regulating mRNA decay. PMID: 25342740
2. the Drosophila melanogaster dTIS11 protein is short-lived due to its rapid ubiquitin-independent degradation by the proteasome. PMID: 25246635
3. Nuclear export of TIS11 proteins is mediated by CRM1 through diverging nuclear export signals, while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 folding. PMID: 23951221
4. overexpression of dTIS11 does not promote the localization of ARE-containing mRNAs in P-bodies but rather decreases the accumulation of CecA1 mRNA in these structures by enhancing the degradation process PMID: 22932903
5. study identified a novel mRNA target of DTIS11, eya, and provided evidence that DTIS11 regulates eye development by interacting with and destabilizing eya mRNA, especially during embryogenesis PMID: 22553461
6. The functionality of CecA1 ARE relies on its ability to recruit TIS11 protein, which accelerates CecA1 mRNA deadenylation and decay PMID: 19176529

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KEGG: dme:Dmel_CG4070

STRING: 7227.FBpp0073516

UniGene: Dm.4329