Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) tll Polyclonal antibody

Uniprot No.

P18102

Target Names

tll

Alternative Names

tll antibody; NR2E2 antibody; CG1378 antibody; Protein tailless antibody; Nuclear receptor subfamily 2 group E member 2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) tll protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate.

Gene References into Functions

TLL is a newly-identified component of a combinatorial network of repressor genes that control pair-rule stripe formation in the anterior blastoderm of Drosophila. PMID: 27773632
Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both proteins physically interact in the PI. tll knockdown-induced aggression is fully suppressed by blocking neuropeptide processing or release from the PI PMID: 24495972
tll regulates the precise timing of the transition from neuroepithelial cells to medulla neuroblasts; tll has a crucial role for the specification of lamina precursor cells PMID: 26111972
Both position and timing of posterior segmentation gene expression domains vary strongly from embryo-to-embryo in tll mutants. PMID: 23333944
drm is activated under the control of tll and triggers development of the small intestine cell-non-autonomously through some extracellular signaling PMID: 22252491
TTK69 is required for early (before the end of stage 4) repression of tll transcription. PMID: 12128207
Tailless-mediated repression of kni expression is impaired in brakeless mutants. PMID: 17503969
Mutations of tll progressively impair cell cycle in MB-Nbs and cause premature loss of MB-Nbs in the early pupal stage. TLL is also expressed in MB-GMCs to prevent apoptosis and promote cell cycling. Ectopic expression of tll leads to brain tumors. PMID: 19084514

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Subcellular Location

Nucleus.

Protein Families

Nuclear hormone receptor family, NR2 subfamily

Tissue Specificity

Brain and peripheral nervous system.

Database Links

KEGG: dme:Dmel_CG1378

STRING: 7227.FBpp0085071

UniGene: Dm.1906

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tll Antibody

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