Recombinant Drosophila melanogaster Protein tailless (tll)

Code CSB-YP325960DLU
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP325960DLU
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP325960DLU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP325960DLU
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP325960DLU
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
tll
Uniprot No.
Alternative Names
tll; NR2E2; CG1378; Protein tailless; Nuclear receptor subfamily 2 group E member 2
Species
Drosophila melanogaster (Fruit fly)
Expression Region
1-452
Target Protein Sequence
MQSSEGSPDM MDQKYNSVRL SPAASSRILY HVPCKVCRDH SSGKHYGIYA CDGCAGFFKR SIRRSRQYVC KSQKQGLCVV DKTHRNQCRA CRLRKCFEVG MNKDAVQHER GPRNSTLRRH MAMYKDAMMG AGEMPQIPAE ILMNTAALTG FPGVPMPMPG LPQRAGHHPA HMAAFQPPPS AAAVLDLSVP RVPHHPVHQG HHGFFSPTAA YMNALATRAL PPTPPLMAAE HIKETAAEHL FKNVNWIKSV RAFTELPMPD QLLLLEESWK EFFILAMAQY LMPMNFAQLL FVYESENANR EIMGMVTREV HAFQEVLNQL CHLNIDSTEY ECLRAISLFR KSPPSASSTE DLANSSILTG SGSPNSSASA ESRGLLESGK VAAMHNDARS ALHNYIQRTH PSQPMRFQTL LGVVQLMHKV SSFTIEELFF RKTIGDITIV RLISDMYSQR KI
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate.
Gene References into Functions
  1. TLL is a newly-identified component of a combinatorial network of repressor genes that control pair-rule stripe formation in the anterior blastoderm of Drosophila. PMID: 27773632
  2. Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both proteins physically interact in the PI. tll knockdown-induced aggression is fully suppressed by blocking neuropeptide processing or release from the PI PMID: 24495972
  3. tll regulates the precise timing of the transition from neuroepithelial cells to medulla neuroblasts; tll has a crucial role for the specification of lamina precursor cells PMID: 26111972
  4. Both position and timing of posterior segmentation gene expression domains vary strongly from embryo-to-embryo in tll mutants. PMID: 23333944
  5. drm is activated under the control of tll and triggers development of the small intestine cell-non-autonomously through some extracellular signaling PMID: 22252491
  6. TTK69 is required for early (before the end of stage 4) repression of tll transcription. PMID: 12128207
  7. Tailless-mediated repression of kni expression is impaired in brakeless mutants. PMID: 17503969
  8. Mutations of tll progressively impair cell cycle in MB-Nbs and cause premature loss of MB-Nbs in the early pupal stage. TLL is also expressed in MB-GMCs to prevent apoptosis and promote cell cycling. Ectopic expression of tll leads to brain tumors. PMID: 19084514

Show More

Hide All

Subcellular Location
Nucleus.
Protein Families
Nuclear hormone receptor family, NR2 subfamily
Tissue Specificity
Brain and peripheral nervous system.
Database Links

KEGG: dme:Dmel_CG1378

STRING: 7227.FBpp0085071

UniGene: Dm.1906

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1