let-363 Antibody

Code CSB-PA836117XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans let-363 Polyclonal antibody
Uniprot No.
Target Names
let-363
Alternative Names
let-363 antibody; CeTor antibody; B0261.2 antibody; Target of rapamycin homolog antibody; EC 2.7.11.1 antibody; CeTOR antibody; Lethal protein 363 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans let-363 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insulin signaling and nutrient sensing.
Gene References into Functions
  1. Dafachronic acid signaling through let-363 is essential for diet restriction-mediated longevity. PMID: 25209682
  2. influence on lifespan PMID: 14668850
  3. C. elegans target of rapamycin (TOR) and the DAF-2/insulin-signaling pathways cross-talk with pep-2 PMID: 15155758
  4. Mutations result in dauer-like larval arrest, implying that CeTOR (let-363)regulates dauer diapause. PMID: 15253933
Subcellular Location
Nucleus.
Protein Families
PI3/PI4-kinase family
Tissue Specificity
Ubiquitous. Expressed in all major tissues and organs, including the intestine, gonads and hypodermal cells. Expressed in neurons.
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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