TRAPPC4 Antibody

Code CSB-PA897085XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRAPPC4 Polyclonal antibody
Uniprot No.
Target Names
TRAPPC4
Alternative Names
TRAPPC4 antibody; SBDN antibody; CGI-104 antibody; HSPC172 antibody; PTD009 antibody; Trafficking protein particle complex subunit 4 antibody; Hematopoietic stem/progenitor cell protein 172 antibody; Synbindin antibody; TRS23 homolog antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) TRAPPC4 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.
Gene References into Functions
  1. Overexpression of TRAPPC4 increased colorectal carcinogenesis. PMID: 23625650
  2. Synbindin contributes to malignant phenotypes of GC by activating ERK on the Golgi, and synbindin is a potential biomarker and therapeutic target for GC. PMID: 24104608
  3. Data demonstrate that TRAPPC4 may regulate cell proliferation and apoptosis in CRC by interaction with ERK2 and phosphorylating ERK1/2 as well as modulating the subcellular location of pERK1/2 to activate the relevant signaling pathway. PMID: 21826244
  4. The three-dimensional structure of human synbindin, which contains a longin domain and an atypical PDZ domain is presented. PMID: 18466758
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane. Golgi apparatus membrane. Endoplasmic reticulum. Vesicle.
Protein Families
TRAPP small subunits family, TRAPPC4 subfamily
Database Links

HGNC: 19943

OMIM: 610971

KEGG: hsa:51399

STRING: 9606.ENSP00000436005

UniGene: Hs.132760

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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