Recombinant Human Trafficking protein particle complex subunit 4 (TRAPPC4)

Code CSB-YP897085HU
MSDS
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Source Yeast
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Code CSB-EP897085HU
MSDS
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Source E.coli
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Code CSB-EP897085HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP897085HU
MSDS
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Source Baculovirus
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Code CSB-MP897085HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
TRAPPC4
Uniprot No.
Alternative Names
TRAPPC4; SBDN; CGI-104; HSPC172; PTD009; Trafficking protein particle complex subunit 4; Hematopoietic stem/progenitor cell protein 172; Synbindin; TRS23 homolog
Species
Homo sapiens (Human)
Expression Region
1-219
Target Protein Sequence
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.
Gene References into Functions
  1. Overexpression of TRAPPC4 increased colorectal carcinogenesis. PMID: 23625650
  2. Synbindin contributes to malignant phenotypes of GC by activating ERK on the Golgi, and synbindin is a potential biomarker and therapeutic target for GC. PMID: 24104608
  3. Data demonstrate that TRAPPC4 may regulate cell proliferation and apoptosis in CRC by interaction with ERK2 and phosphorylating ERK1/2 as well as modulating the subcellular location of pERK1/2 to activate the relevant signaling pathway. PMID: 21826244
  4. The three-dimensional structure of human synbindin, which contains a longin domain and an atypical PDZ domain is presented. PMID: 18466758
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane. Golgi apparatus membrane. Endoplasmic reticulum. Vesicle.
Protein Families
TRAPP small subunits family, TRAPPC4 subfamily
Database Links

HGNC: 19943

OMIM: 610971

KEGG: hsa:51399

STRING: 9606.ENSP00000436005

UniGene: Hs.132760

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