trc Antibody

Code CSB-PA882036XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) trc Polyclonal antibody
Uniprot No.
Target Names
trc
Alternative Names
trc antibody; CG8637 antibody; Serine/threonine-protein kinase tricorner antibody; EC 2.7.11.1 antibody; NDR protein kinase antibody; Serine/threonine-protein kinase 38-like antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) trc protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Serine/threonine-protein kinase involved in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Together with fry, maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Reduces neurite outgrowth by phosphorylating pav, thereby inhibiting its function in microtubule-microtubule sliding.
Gene References into Functions
  1. Data show that Tricornered Kinase (Trc) regulates the Wiskott-Aldrich syndrome protein (WASP) levels largely, by regulating the transcription of WASP. PMID: 26393506
  2. The regulation of Warts conformation by Mats, Fat/Dachsous signaling, and Dachs appears independent of Warts phosphorylation by Hippo kinase, establishing a precedent for the control of Nuclear Dbf2-related kinases PMID: 26702832
  3. Mutations in trc and wts genes lead to changes in cell shape, cellular levels of F-actin, the timing of differentiation, and the expression of multiple wing hairs and DE-Cadherin. PMID: 20211163
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Tissue Specificity
Expressed in the peripheral and central nervous system (at protein level). Expressed in the wing imaginal disk.
Database Links

KEGG: dme:Dmel_CG8637

STRING: 7227.FBpp0304464

UniGene: Dm.2518

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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