Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) trpl Polyclonal antibody

Uniprot No.

P48994

Target Names

trpl

Alternative Names

trpl antibody; CG18345 antibody; Transient-receptor-potential-like protein antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) trpl protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins.

Gene References into Functions

The effect of experimental infection with P. aeruginosa on trpl expression in male Drosophila melanogaster flies from different genetic backgrounds exposed by pricking or by ingestion showed downregulation in the whole body and the intestines. The downregulation of trpl in gammaCop mutant males is not confirmed by qRT-PCR data. PMID: 29616531
effects of cholesterol depletion on the TRPL channel activity PMID: 28863818
CG17352 (CULD) plays an important role in the endocytic turnover of Rh1 and TRPL. PMID: 26598556
conclusion, TTD14 is a novel regulator of TRPL trafficking, involved in internalization and subsequent sorting of TRPL into the recycling pathway that enables this ion channel to return to the plasma membrane PMID: 26509977
The transient receptor potential-like (TRPL) cation channel is a direct target for camphor in gustatory receptor neurons; long-term feeding on a camphor diet leads to reversible downregulation of TRPL protein concentrations. PMID: 24013593
TRP and TRPL assemble exclusively as homomultimeric channels in their native environment. PMID: 23687378
a light-dependent switch in the phosphorylation pattern of the TRPL channel mediates stable expression of TRPL in the rhabdomeres upon prolonged dark-adaptation. PMID: 23592784
These observations show that reduction in TRPC channel function significantly reduces the sensitivity of the olfactory response to CO(2) concentrations of 5% or less in adult Drosophila PMID: 23185459
TRPL channel is constitutively active in S2 cells but is silent in HEK cells. PMID: 22627924
The involvement of de novo protein synthesis in TRPL translocation, was examined. PMID: 22363689
PI(4,5)P(2) is a crucial substrate for PLC-mediated activation of the trpl channels, whereas PUFA may function as the channel activator. PMID: 22065576
the essential function of the TRP channels in TRPL translocation is to enhance Ca(2+)-influx. PMID: 21816824
TRPL translocation represents a novel mechanism to fine tune visual responses. PMID: 11931743
Arrestin2 is required for the rhabdomeric localization and stability of TRPL channels. PMID: 16787936
Whole cell recordings from a Drosophila mutant expressing only TRPL indicated that Ca(2+) block also accounts for the voltage dependence of the native TRPL channels. PMID: 17190901
TRPL and TRP are required for cool avoidance; however they are dispensable for warm avoidance PMID: 18787131
the unitary currents from Drosophila trpl and trp photoreceptors correspond to TRP and TRPL. PMID: 19261713

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Subcellular Location

Membrane; Multi-pass membrane protein. Note=In the dark, there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light, the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions.

Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily

Tissue Specificity

Expressed predominantly in the rhabdomeres of photoreceptor cells.

Database Links

KEGG: dme:Dmel_CG18345

STRING: 7227.FBpp0290876

UniGene: Dm.546

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trpl Antibody

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