tdp2 Antibody

Datasheet

Code	CSB-PA723059XA01DIL
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Product Details

Full Product Name

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) tdp2 Polyclonal antibody

Uniprot No.

Q5XJA0

Target Names

tdp2

Alternative Names

tdp2 antibody; ttrap antibody; ttrapl antibody; si:ch211-81e5.5 antibody; si:dkey-218n20.5Tyrosyl-DNA phosphodiesterase 2 antibody; Tyr-DNA phosphodiesterase 2 antibody; EC 3.1.4.- antibody; 5'-tyrosyl-DNA phosphodiesterase antibody; 5'-Tyr-DNA phosphodiesterase antibody; TRAF and TNF receptor-associated protein homolog antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) tdp2 protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. Controls gastrulation movements and left/right (L/R) axis determination via smad3-mediated regulation of cdh1/e-cadherin. Regulates the formation of Kupffer's vesicle, a signaling center essential for establishing L/R asymmetry. Modulates smad3 activity through modulating nodal-acvr1/akt4 signaling.

Subcellular Location

Nucleus. Nucleus, PML body.

Protein Families

CCR4/nocturin family, TTRAP/TDP2 subfamily

Tissue Specificity

Expressed ubiquitously during blastula stages and throughout gastrulation. Shortly after shield formation, expressed weakly in dorsal forerunner cells (DFCs). Between somite stages 5 and 9, expressed in the tailbud and around the Kupffer's vesicle at a hi

Database Links

KEGG: dre:553516

STRING: 7955.ENSDARP00000094388

UniGene: Dr.18071

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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tdp2 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background