Tdo2 Antibody

Code CSB-PA023351ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Tdo2 Polyclonal antibody
Uniprot No.
Target Names
Tdo2
Alternative Names
Tdo2 antibody; Tdo antibody; Tryptophan 2,3-dioxygenase antibody; TDO antibody; EC 1.13.11.11 antibody; Tryptamin 2,3-dioxygenase antibody; Tryptophan oxygenase antibody; TO antibody; TRPO antibody; Tryptophan pyrrolase antibody; Tryptophanase antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus
Immunogen
Recombinant Rattus norvegicus Tdo2 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Gene References into Functions
  1. Results show that stress-induced corticosterone and consequent activation of hepatic TDO, tryptophan metabolism and production of kynurenine provoke a depression-related behavioural phenotype PMID: 24472498
  2. tryptophan oxygenase gene might rely on the binding of the enhancer (the -8.5kb S/MAR-GRE) and the promoter to the inner nuclear matrix. PMID: 19632204
  3. Data support the involvement of insulin in modulation of glucocorticoid receptor signaling pathway which mediates, in part, the activity of tryptophan oxygenase. PMID: 17223727
  4. these data show that the nucleosome array in the regulatory region of the actively transcribed tdo gene in vivo is disturbed. PMID: 20737904
  5. The cerebrocortical TDO2 genes were increased in aged rats. Certain age dependent transcriptional changes might influence the mechanism of Alzheimer dis and other neurodegenerative disorders. PMID: 19835274

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Protein Families
Tryptophan 2,3-dioxygenase family
Tissue Specificity
Liver.
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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