Tet2 Antibody

Datasheet
Code CSB-PA678395ZA01MO
Uniprot No. Q4JK59
Delivery Make-to-order
Immunogen Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2), partial (1810-1912AA)
Raised in Rabbit
Species Reactivity Mus musculus
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Methylcytosine dioxygenase TET2 (EC 1.14.11.n2) (Protein Ayu17-449), Tet2, Kiaa1546
Immunogen Species Mus musculus (Mouse)
Protocols ELISA Protocol
Gene Names Tet2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Protein Families TET family
Tissue Specificity Highly expressed in the brain, kidney, heart, lung, muscle and stomach. Present in embryonic stem cells (ES cells).
Database Links

KEGG: mmu:214133

STRING: 10090.ENSMUSP00000096203

UniGene: Mm.347816

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