Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
The following TET2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TET2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA023397GA01HU | TET2 Antibody |
Human | ELISA,WB |
CSB-PA764560ESR1HU | TET2 Antibody |
Human | ELISA, IHC |
TET2 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA212085XA01DOA | TET2 Antibody |
Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
TET2 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA678395ZA01MO | Tet2 Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
TET2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP678395MO CSB-BP678395MO CSB-MP678395MO CSB-EP678395MO-B |
Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP678395MO | Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2), partial |
E.coli |
TET2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP764560HU CSB-EP764560HU CSB-BP764560HU CSB-MP764560HU CSB-EP764560HU-B |
Recombinant Human Methylcytosine dioxygenase TET2 (TET2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |