Cltrn Antibody

Code CSB-PA861705ZA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Cltrn Polyclonal antibody
Uniprot No.
Target Names
Cltrn
Alternative Names
Cltrn antibody; Nx17 antibody; Tmem27Collectrin antibody; Transmembrane protein 27 antibody
Raised in
Rabbit
Species Reactivity
Mus musculus
Immunogen
Recombinant Mus musculus Cltrn protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Gene References into Functions
  1. this study shows that Tmem27-mediated cross-presentation supports intrahepatic adaptive antiviral immune responses and may lead to insights into the nature of how the liver acts as a primary site of CD8+ T cell activation PMID: 28159899
  2. Collectrin is a consequential link between the transport of l-arginine and endothelial nitric oxide synthase uncoupling in hypertension. PMID: 24048198
  3. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
  4. Tmem27 is a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets PMID: 16330324
  5. Our data suggest that collectrin is a novel mediator of renal amino acid transport and may provide further insight into the pathogenesis of a number of human disease correlates. PMID: 16985211
  6. data identify collectrin as a key regulator of renal amino acid uptake PMID: 17167413
  7. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
  8. functional association of mutant B(0)AT1 transporters with ACE2 and collectrin in intestine and kidney, respectively, participates in the phenotypic heterogeneity of Hartnup disorder PMID: 19185582
  9. These data indicate the involvement of mitochondrial TCA cycle intermediates, distal to pyruvate, in the regulation of collectrin protein expression in beta-cells. PMID: 19715677

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
TMEM27 family
Tissue Specificity
Expressed on the apical surface of the proximal tubules in the renal cortex (at protein level). Kidney; collecting ducts and proximal tubule. Pancreas; beta cells of islets.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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