UBA1 Antibody

Code CSB-PA322174XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) UBA1 Polyclonal antibody
Uniprot No. P22515
Target Names UBA1
Alternative Names UBA1 antibody; YKL210W antibody; Ubiquitin-activating enzyme E1 1 antibody; EC 6.2.1.45 antibody
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) UBA1 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
Gene References into Functions
  1. Crystal structure of UBA1 with one ubiquitin, which is bound in its adenylated form to the active adenylation domain of UBA1, and the the second ubiquitin is covalently linked to the active-site cysteine. PMID: 24816100
  2. isolation of uba1-204, a temperature-sensitive allele of the essential E1 gene, UBA1 PMID: 17360968
Subcellular Location Cytoplasm. Nucleus.
Protein Families Ubiquitin-activating E1 family
Database Links

KEGG: sce:YKL210W

STRING: 4932.YKL210W

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