unc-51 Antibody

Code CSB-PA635495XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-51 Polyclonal antibody
Uniprot No.
Target Names
unc-51
Alternative Names
unc-51 antibody; Y60A3A.1 antibody; Serine/threonine-protein kinase unc-51 antibody; EC 2.7.11.1 antibody; Uncoordinated protein 51 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-51 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell size. Plays a role in male tail ray pattern formation. May be required for normal dauer morphogenesis.
Gene References into Functions
  1. Mutants with impaired growth cone functions, such as unc-51, often exhibit abnormal terminations and inappropriate trajectories at the distal ends of the M2 axons. PMID: 12885562
  2. The autophagy-related kinase UNC-51 regulates the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans PMID: 16887826
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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