ung Antibody

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Code	CSB-PA025641XA01ENV
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) ung Polyclonal antibody

Uniprot No.

P12295

Target Names

ung

Alternative Names

ung antibody; b2580 antibody; JW2564 antibody; Uracil-DNA glycosylase antibody; UDG antibody; EC 3.2.2.27 antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) ung protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

Gene References into Functions

A mutant uracil DNA glycosylase distinguishes between cytosine and 5-methylcytosine. PMID: 24740413
Contrasting effects of mutating active site residues, aspartic acid 64 and histidine 187 of Escherichia coli uracil-DNA glycosylase on uracil excision and interaction with an inhibitor protein PMID: 22905376
oligonucleotide substrates containing two uracil residues in defined positions were used to characterize one-dimensional search of DNA by Escherichia coli Ung. PMID: 21971549
The significance of the Ung residency on the AP-site in the uracil excision repair pathway in E. coli. PMID: 20056657
negatively regulated by the two-component system of CpxR/CpxA signal transduction. PMID: 15576781
A synthetic DNA duplex of uracil DNA glycosylase contains an excellent isostere of uracil but lacks hydrogen bonds and acceptor groups; it attains a metastable unstacked state that mimics a previously detected intermediate on the uracil-flipping pathway. PMID: 15581354
The structure of native and modified uracil DNA glycosylase from E. coli in solution was studied by synchrotron small-angle X-ray scattering. PMID: 16521548
influence of the ung, dug, and dut genes in preventing uracil residues from accumulating in E. coli DNA was quantitatively determined PMID: 16908222
for the human and Escherichia coli UNG enzymes, discrimination of thymine and uracil is initiated by thermally induced opening of T*A and U*A base pairs and not by active participation of the enzyme PMID: 17704764

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Subcellular Location

Cytoplasm.

Protein Families

Uracil-DNA glycosylase (UDG) superfamily, UNG family

Database Links

KEGG: ecj:JW2564

STRING: 316385.ECDH10B_2748

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Related pathways

DNA repair pathway

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ung Antibody

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