VAV Antibody

^{Rare Species}

Datasheet

Code	CSB-PA889053XA01DLU
Size	US$299
Image	Western Blot Positive WB detected in Recombinant protein All lanes: VAV antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 57.4 kDa Observed band size: 58 kDa
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Product Details

Uniprot No.

Q9NHV9

Target Names

VAV

Alternative Names

Protein vav (DroVav) (dVAV) Vav CG7893

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) VAV protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Protein G

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The VAV polyclonal antibody is produced by introducing recombinant Drosophila melanogaster (Fruit fly) VAV protein into a rabbit, which stimulates the production of antibodies that specifically target this antigen. Antibody production is further enhanced through a booster injection, and the resulting VAV polyclonal antibodies in the rabbit's serum are collected and purified using protein A/G. Rigorous testing conducted in ELISA and WB assays has verified the VAV antibody's ability to recognize Drosophila melanogaster (Fruit fly) VAV protein.

The Drosophila melanogaster VAV protein mainly acts as a guanine nucleotide exchange factor (GEF) for small GTPases of the Rho family. It plays a crucial role in regulating the actin cytoskeleton and cell signaling pathways. The VAV protein is involved in various cellular processes such as cell migration, cell adhesion, and cell proliferation. Additionally, it is also implicated in the development and function of the nervous system in fruit flies.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development.

Gene References into Functions

Findings establish that Vav acts at multiple times during eye development to prevent excessive cell recruitment by limiting EGFR signalling and by regulating junction dynamics to ensure the correct patterning and morphogenesis of the Drosophila eye. PMID: 25813543
regulator of Rac activity in a developmentally regulated cell migration PMID: 23525006
vav acts in coordination with other GEFs to regulate axon growth and guidance during development by linking guidance signals to the cytoskeleton via the modulation of Rac activity PMID: 20147552
DroVav has a role as a signal transducer that participates in receptor tyrosine kinase pathways and functions as a GEF for the small RhoGTPase, DRac PMID: 14555990

Tissue Specificity

Ubiquitous.

Database Links

KEGG: dme:Dmel_CG7893

STRING: 7227.FBpp0112228

UniGene: Dm.218

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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VAV Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background