VGF Antibody

Code CSB-PA769695XA01VAD
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Product Details

Full Product Name
Rabbit anti-Vaccinia virus (strain L-IVP) (VACV) VGF Polyclonal antibody
Uniprot No.
Target Names
VGF
Alternative Names
VGF antibody; Pro-vaccinia growth factor antibody; Pro-VGF) [Cleaved into: Vaccinia growth factor antibody; VGF antibody; Secreted epidermal growth factor-like)] antibody
Raised in
Rabbit
Species Reactivity
Vaccinia virus (strain L-IVP) (VACV)
Immunogen
Recombinant Vaccinia virus (strain L-IVP) (VACV) VGF protein
Immunogen Species
Vaccinia virus (strain L-IVP) (VACV)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Vaccinia growth factor stimulates cellular proliferation (hyperplasia) around infected cells. This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells. Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival. The activation by host EGFR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo.
Subcellular Location
[Pro-vaccinia growth factor]: Host membrane; Single-pass type I membrane protein.; [Vaccinia growth factor]: Secreted.
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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