Vps36 Antibody

Code CSB-PA892898XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Vps36 Polyclonal antibody
Uniprot No.
Target Names
Vps36
Alternative Names
Vps36 antibody; CG10711Vacuolar protein-sorting-associated protein 36 antibody; ESCRT-II complex subunit VPS36 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Vps36 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid mRNA in the developing egg. Plays a role in promoting mitochondrial autophagy (mitophagy).
Gene References into Functions
  1. vps36 mutations increase apoptotic resistance, but have little effect on non-autonomous proliferation. PMID: 19132102
Subcellular Location
Cytoplasm.
Protein Families
VPS36 family
Tissue Specificity
Ubiquitously expressed in the ovary.
Database Links

KEGG: dme:Dmel_CG10711

STRING: 7227.FBpp0075560

UniGene: Dm.7252

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