vpx Antibody

Code CSB-PA356976XA01HLZ
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Product Details

Full Product Name
Rabbit anti-Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) vpx Polyclonal antibody
Uniprot No.
Target Names
vpx
Alternative Names
vpxProtein Vpx antibody; Viral protein X antibody; X ORF protein antibody
Raised in
Rabbit
Species Reactivity
Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)
Immunogen
Recombinant Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) vpx protein
Immunogen Species
Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Subcellular Location
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein Families
Lentivirus VPX protein family
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Address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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