Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx(vpx),Yeast

Code CSB-YP356976HLZ
Product Type Recombinant Protein
Size US$2959
Uniprot No. P06939
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Tris-based buffer,50% glycerol
Species Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)
Purity >85% (SDS-PAGE)
Sequence MTDPRETVPP GNSGEETIGE AFAWLNRTVE AINREAVNHL PRELIFQVWQ RSWRYWHDEQ GMSESYTKYR YLCIIQKAVY MHVRKGCTCL GRGHGPGGWR PGPPPPPPPG LV
Source Yeast
Gene Names Name:vpx
Protein Names Recommended name: Protein VpxAlternative name(s): Viral protein X X ORF protein
Expression Region 1-112
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
Protein Description full length protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
Subcellular Location Virion, Host nucleus
Protein Families Lentivirus VPX protein family

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