wts Antibody

1. Results demonstrate distinct lipid metabolism defects elicited in hypoxia as well as a novel role for insulin signaling and Warts function in the adaptation to low oxygen availability. PMID: 25541690
2. In the normal epithelium, JNK signaling antagonizes the Hippo pathway effector Yorkie (Yki) through elevation of Warts activity, thereby suppressing tissue growth. In contrast, in the presence of hyperactive Ras, JNK signaling enhances Yki activation by accumulating F-actin through the activity of the LIM domain protein Ajuba, thereby promoting tissue growth. PMID: 25967126
3. The Warts pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. PMID: 22075147
4. The warts protein pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. PMID: 22075148
5. Drosophila wts mutations are recessive lethal and homozygous clones in heterozygotes lead to epithelial tumors PMID: 12489118
6. Data report the identification of Hippo, which regulates both cell proliferation and cell death in Drosophila and phosphorylates the tumor suppressor protein Salvador, which interacts with the Warts protein kinase. PMID: 12941273
7. Data show that Hippo links Salvador and Warts to a key regulator of apoptosis PMID: 12941274
8. Results suggest that Hippo acts together with Salvador and Warts in a signalling module that coordinately regulates cell proliferation and apoptosis. PMID: 14502294
9. Data show that warts genes are dispensable in germline cells for their proliferation control. PMID: 18095349
10. Wts may be regulated by distinct junction inputs depending on developmental context. PMID: 18430928
11. regulates salivary gland cell death in a PI3K-dependent manner PMID: 18818081

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KEGG: dme:Dmel_CG12072

STRING: 7227.FBpp0085082

UniGene: Dm.4172