wnt8a Antibody

1. In the Wnt-receiving cells, Wnt8a on cytonemes triggers Wnt/beta-catenin-dependent gene transcription and proliferation. We show that cytoneme-based Wnt transport operates in diverse processes, including zebrafish development, murine intestinal crypt and human cancer organoids, demonstrating that Wnt transport by cytonemes and its control via the Ror2 pathway is highly conserved in vertebrates PMID: 30060804
2. The results demonstrate that the argon plasma jet has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt)/beta-Catenin-signaling pathways. PMID: 28706297
3. These results indicated that maternal wnt8a is dispensable for the initial dorsal determination, but cooperates with zygotic wnt8a for ventrolateral and posterior tissue formation. PMID: 29208373
4. Wnt signaling balances specification of the cardiac and pharyngeal muscle fields. PMID: 28087459
5. Data suggest that Wnt3, Wnt3a, and Wnt8a bind to their respective receptors (Fz8, Lrp6, and Lypd6) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt proteins to their receptor complexes and stimulation of downstream signaling activity. PMID: 28626941
6. Wnt8, in addition to its well-established role in posterior mesoderm patterning, also plays a later role as a factor that expands the renal progenitor pool prior to kidney morphogenesis. PMID: 28359809
7. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl, in the zebrafish embryo have been presented. PMID: 26528729
8. Gain of function of Wnt8a results in the accumulation of beta-catenin into the nuclei of all cells of the gastrula from the margin to the animal pole. PMID: 25371059
9. A filopodia-based transport system for Wnt8a controls anteroposterior patterning of the neural plate during vertebrate gastrulation. PMID: 25556612
10. Wnt limits its own signaling activity in part via up-regulation of a transporter, slc35c1 that promotes terminal fucosylation and thereby limits Wnt activity. PMID: 25238963
11. Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm. PMID: 24427298
12. post-transcriptional control of wnt8a is essential to fine tune the balance of the signaling outputs of the complex wnt8a locus, which is essential to zebrafish axis development PMID: 24333179
13. A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/beta-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity. PMID: 23364330
14. Wnt8a expression pattern reflects complex interactions of multiple regulatory inputs. PMID: 22473868
15. 2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function PMID: 22357927
16. It was shown that Wnt3a-Wnt8a/beta-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle. PMID: 22190638
17. wnt8a expression marks Nodal-independent tail mesoderm formation and that Ntl/Bra predominantly regulates wnt8a in paraxial mesoderm progenitors. PMID: 21384472
18. Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation PMID: 20978132
19. Wnt8 and BMP signaling have independent roles during vertebrate ventrolateral mesoderm development that can be identified through loss-of-function analysis. PMID: 20845427
20. wnt8 has a role as neural posteriorizing factor and Frizzled 8c and Frizzled 9 are its functional receptors PMID: 12676325
21. Loss-of-function experiments reveal that bone morphogenetic protein (BMP), Nodal and Wnt8 signalling pathways are required for tail development PMID: 12879074
22. Wnt8 achieves restriction on size of dorsal organizer by regulating the early expression of Vent and Vox. PMID: 15269175
23. FoxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a. PMID: 16364286
24. In addition to its role in midbrain-hindbrain formation, we have shown that gbx1 is a novel mediator of Wnt8 signaling during hindbrain patterning. PMID: 19341460

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KEGG: dre:30122

STRING: 7955.ENSDARP00000116057

UniGene: Dr.309