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| Code | CSB-PA524867XA01SXV |
| Size | Enquire |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) wtf18 Polyclonal antibody |
| Uniprot No. | O74495 |
| Target Names | wtf18 |
| Alternative Names | wtf18; wtf5; SPCC285.07c; Meiotic drive suppressor wtf18 |
| Raised in | Rabbit |
| Species Reactivity | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Immunogen | Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) wtf18 protein |
| Immunogen Species | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein A/G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
| Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
| Lead Time | Made-to-order (14-16 weeks) |
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| Function (From Uniprot) |
Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons. Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole. Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote. |
| Subcellular Location | Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. |
| Protein Families | WTF family |
| Database Links |
KEGG: spo:SPCC285.07c STRING: 4896.SPCC285.07c.1 |
