Wwox Antibody

Code CSB-PA893301XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Wwox Polyclonal antibody
Uniprot No.
Target Names
Wwox
Alternative Names
Wwox antibody; CG7221 antibody; WW domain-containing oxidoreductase antibody; EC 1.1.1.- antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Wwox protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling.
Gene References into Functions
  1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. PMID: 26390919
  2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity. PMID: 26302329
  3. Aberrant WWOX expression contributes to the altered metabolism in cancer. PMID: 25595186
  4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX PMID: 21075834
  5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX PMID: 16007179

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Subcellular Location
Cytoplasm.
Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Database Links

KEGG: dme:Dmel_CG7221

STRING: 7227.FBpp0079172

UniGene: Dm.19795

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